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邵彦平 (Shao, Yanping Charles), MD, Ph.D.
Attending and Clinical Associate Professor
病理学 | 神经病理
诊所：
治疗神经病理学(Therapath Neuropathology)
545 W 45th St,
New York, NY 10036 US (Get Direction)
电话：800-681-4338
教育和训练背景：
医科大学： 首都医科大学(Capital Medical University)
住院医师： NYU Medical Center
专科训练： NYU Medical Center
临床兴趣：
神经病理。
语言：
除了英语以外，邵医生还能讲普通话
Ph.D.: Emory University , Atlanta, GA 1985-1990
Research Interests: I am interested in the pathogenesis of
neurodegenerative diseases, especially
Alzheimer's Disease (AD) the most common form of memory disorders. Accumulating evidence has
indicated that synaptic plasticity such as long-term potentiation (LTP) that underlines learning and
memory is impaired in AD. I currently focus on an unique molecule called PKMzeta that plays a
critical role in LTP maintenance and memory function in living animals. I have found that PKMzeta
associates with a variety of AD pathology that mark changes of postsynaptic structures such as
Hirano bodies (dendritic spines), perisomatic granules (AMPA receptors) and granulovacular
degeneration. I postulate that PKMzeta regulate these structures during memory formation and their
aggregation during AD lead to memory loss. Using primary cultures of hippocampal neurons, I
demonstrate that PKMzeta indeed positively regulates synaptic structures and AMPA receptors. Further
studies will explore what alters PKMzeta in neurons and how PKMzeta may play a role in combating AD.
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